منابع مشابه
Shark Immunoglobulin Light Chains
The humoral adaptive immune system of sharks is partly based on the same H2L2 heterodimeric antibody structure seen in all jawed vertebrates (reviewed in Flajnik 2002). The constituent vertebrate immunoglobulin (Ig) heavy (H) and light (L) chains provide obligate defense against pathogens and their toxins via neutralization, opsonization, and activation of the classical pathway of the complemen...
متن کاملImmunoglobulin light (IgL) chains in ectothermic vertebrates.
Four major ancesteral IgL isotypes have been identified κ, λ, σ and σ-cart. However, depending on the vertebrate class the genomic representation of these isotypes differs in regards to what is encoded in the germline and how these genes are organized. Also, the relative contribution of each isotype in immune responses varies. This review focuses on the IgL chains of ectothermic vertebrates, sp...
متن کاملHuman Autoantibody Silencing by Immunoglobulin Light Chains
Several newly arising human antibodies are polyreactive, but in normal individuals the majority of these potentially autodestructive antibodies are removed from the repertoire by receptor editing or B cell deletion in the bone marrow. To determine what proportion of naturally arising autoantibodies can be silenced by immunoglobulin (Ig) light chain receptor editing, we replaced the light chains...
متن کاملFree immunoglobulin light chains in connective tissue diseases.
The basic immunoglobulin subunit consists of two heavy and two light chains held together by covalent disulphide bonds. In most cases of myeloma and Waldenstrom's disease there is an excess synthesis of light over heavy chains, resulting in Bence Jones proteinaemia and proteinuria. Furthermore, in some cases ("light chain disease"), there is absence of detectable heavy chain synthesis, and the ...
متن کاملA new variable region in mouse immunoglobulin lambda light chains
A series of lambda+ murine hybridomas were derived from a BALB/c mouse after a single injection of anti-lambda 2 antibodies coupled to LPS. Nine lambda B cell clones (five lambda 2 and four lambda 3) were expected and seven reacted with antibodies specific for the C lambda 2 constant region but showed a particular isoelectric spectrum. Their RNA products did not hybridize with the V lambda prob...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2003
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.63.s84.8.x